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A system of physical units in which the fundamental quantities are length, time, mass, electric current, temperature, luminous intensity, and amount …

Microscopic study of the spacial distribution pattern of CHROMATIN in CELL NUCLEI and CELL NUCLEOLI.

A scanning microscope-based, cytofluorimetry technique for making fluorescence measurements and topographic analysis on individual cells. Lasers are …

Obtaining material for pathological examination and analysis, from bodily fluids. Material retrieved includes CELL-FREE NUCLEIC ACIDS; CELL-DERIVED M…

Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.

Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells whi…

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations,…

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-…

A computer simulation technique that is used to model the interaction between two molecules. Typically the docking simulation measures the interactio…

A computer simulation developed to study the motion of molecules over a period of time.

The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate partic…

A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for MOLECULARL…

The use of devices which use detector molecules to detect, investigate, or analyze other molecules, macromolecules, molecular aggregates, or organism…

The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneousl…

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

A sequencing protocol that drives nucleic acids (DNA or RNA) in an electric field through NANOPORES allowing single molecule sequence analysis.

Irrigation of the nose with saline or irrigation solutions for diagnostic or therapeutic purposes. It is used to remove irritants, allergens, or micr…

Experimental transplantation of neoplasms in laboratory animals for research purposes.

The scattering of NEUTRONS by matter, especially crystals, with accompanying variation in intensity due to interference effects. It is useful in CRYS…

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, a…

Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is melted by dissociation of the …

Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double …

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a …

A technique to generate restriction maps from single large DNA molecules by spreading the DNA onto a glass surface, digesting with DNA RESTRICTION EN…

A technique that uses LASERS to trap, image, and manipulate small objects (biomolecules, supramolecular assembles, DENDRIMERS) in three dimensional s…

The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biolo…

A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or …

The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.