Public registry
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Browse canonical concepts by label, domain, node type, prefix and encoded class.
Current membership scope: Any direct membership
| Concept | Node type | Base domain | Matched membership | Identifier |
|---|---|---|---|---|
| Laurence-Moon Syndrome An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. … | Syndrome | Pathology | Nervous System [curated_secondary] | AMW:DIS:100283 |
| Lead Poisoning, Nervous System Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTE… | Toxic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100624 |
| Lead Poisoning, Nervous System, Adult Neurologic conditions in adults associated with acute or chronic exposure to lead or any of its salts. The most common lead related neurologic syndro… | Toxic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100625 |
| Lead Poisoning, Nervous System, Childhood Neurologic disorders occurring in children following lead exposure. The most frequent manifestation of childhood lead toxicity is an encephalopathy a… | Toxic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100626 |
| Leigh Disease A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, visi… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100090 |
| Lennox Gastaut Syndrome A childhood-onset epilepsy syndrome. | Syndrome | Pathology | Nervous System [curated_secondary] | AMW:DIS:100262 |
| Lesch-Nyhan Syndrome An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRAN… | Syndrome | Pathology | Nervous System [curated_secondary] | AMW:DIS:100091 |
| Lethargy A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be r… | Pathologic Condition | Pathology | Nervous System [curated_secondary] | AMW:DIS:100498 |
| Leukoaraiosis Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cel… | Pathologic Condition | Pathology | Nervous System [curated_secondary] | AMW:DIS:230173 |
| Leukodystrophy, Globoid Cell An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100084 |
| Leukodystrophy, Metachromatic An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfat… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100085 |
| Leukoencephalitis, Acute Hemorrhagic A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid… | Inflammatory Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100007 |
| Leukoencephalopathies Any of various diseases affecting the white matter of the central nervous system. | Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100299 |
| Leukomalacia, Periventricular Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily af… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100216 |
| Lewy Body Disease A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifesta… | Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100063 |
| Lissencephaly A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characteri… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100394 |
| Locked-In Syndrome Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye mo… | Syndrome | Pathology | Nervous System [curated_secondary] | AMW:DIS:100538 |
| Lysosomal Storage Diseases, Nervous System A group of enzymatic disorders affecting the nervous system and to a variable degree the skeletal system, lymphoreticular system, and other organs. T… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100092 |
| Machado-Joseph Disease A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and A… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100156 |
| Malformations of Cortical Development Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or A… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100388 |
| Malformations of Cortical Development, Group I Cortical malformations secondary to abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS in NEUROGENESIS. This group includes congenital MICRO… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100389 |
| Malformations of Cortical Development, Group II Cortical malformations secondary to abnormal neuronal CELL MIGRATION in NEUROGENESIS. This group includes COBBLESTONE LISSENCEPHALY and PERIVENTRICUL… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100392 |
| Malformations of Cortical Development, Group III Cortical malformations secondary to abnormal cortical maturation after CELL MIGRATION in NEUROGENESIS. This group includes injury to the cortex durin… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100398 |
| Mandibular Fractures Fractures of the lower jaw. | Traumatic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100663 |
| Mandibular Injuries Injuries to the lower jaw bone. | Traumatic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100665 |
| Manganese Poisoning Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features includ… | Toxic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100627 |
| Mania A state of elevated excitement with over-activity sometimes accompanied with psychotic symptoms (e.g., PSYCHOMOTOR AGITATION, inflated SELF ESTEEM an… | Pathologic Condition | Pathology | Nervous System [curated_secondary] | AMW:DIS:100499 |
| Maple Syrup Urine Disease An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branch… | Congenital Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100113 |
| Marchiafava-Bignami Disease A neurodegenerative condition that is characterized by demyelination or necrosis of the CORPUS CALLOSUM. Symptoms include DEPRESSION; PARANOIA; DEMEN… | Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100131 |
| Maxillary Fractures Fractures of the upper jaw. | Traumatic Disorder | Pathology | Nervous System [curated_secondary] | AMW:DIS:100664 |