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A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with…

The folding of an organism's DNA molecule into a compact, orderly structure that fits within the limited space of a CELL or VIRUS PARTICLE.

The removal of DNA LESIONS and/or restoration of intact DNA strands without BASE PAIR MISMATCHES, intrastrand or interstrand crosslinks, or disconti…

An increase number of repeats of a genomic, tandemly repeated DNA sequence from one generation to the next.

The process by which a DNA molecule is duplicated.

The temporal order in which the DNA of the GENOME is replicated.

The ability of bacterial cells to take up exogenous DNA and be genetically transformed by it.

Dominance of one cerebral hemisphere over the other in cerebral functions.

The functional superiority and preferential use of one eye over the other. The term is usually applied to superiority in sighting (VISUAL PERCEPTION)…

Changes in the observed frequency of waves (as sound, light, or radio waves) due to the relative motion of source and observer. The effect was named …

Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing gen…

The relationship between the dose of an administered drug and the response of the organism to the drug.

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

An RNA-binding motif characterized by an alpha-beta-beta-beta-alpha fold that binds DOUBLE-STRANDED RNA. It occurs in many eukaryotic proteins as wel…

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory s…

The consumption of liquids.

The ability of a plant to adapt in a drought environment and tolerate a reduction in available water.

Prolonged dry periods in natural climate cycle. They are slow-onset phenomena caused by rainfall deficit combined with other predisposing factors.

Phenomena and pharmaceutics of compounds that selectively bind to a specific receptor and trigger a response. They mimic the action of endogenous bio…

Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a speci…

Increase in sensitivity of an organism, disease, or tissue to one drug that develops following the loss of sensitivity (i.e. resistance) to another d…

Various processes through which administered drugs are discharged from the body.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Phenomena and pharmaceutics of compounds that bind to the same receptor binding-site as an agonist (DRUG AGONISM) for that receptor but exerts the op…

Release of drugs from DOSAGE FORMS into solution.

Drug agonism involving selective binding but reduced effect. This can result in some degree of DRUG ANTAGONISM.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from…

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acqu…

The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired t…

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics.…