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Polycyclic Compound

Cardiac Glycosides

AMW:CHEM:040056

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.

Biochemistry chemical
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Graph assertions

Cardiac Glycosides has parent Cardanolides
Bufanolides has parent Cardiac Glycosides
Proscillaridin has parent Cardiac Glycosides
Cardenolides has parent Cardiac Glycosides
Digitalis Glycosides has parent Cardiac Glycosides
Strophanthins has parent Cardiac Glycosides
Cardiac Glycosides has parent Glycosides

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