Macromolecule

Axin Signaling Complex

AMW:CHEM:050006

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

Biochemistry biochemical

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Graph assertions

Adenomatous Polyposis Coli Protein has parent Axin Signaling Complex

Axin Protein has parent Axin Signaling Complex

Casein Kinase I has parent Axin Signaling Complex

Glycogen Synthase Kinase 3 has parent Axin Signaling Complex

Axin Signaling Complex has parent Intracellular Signaling Peptides and Proteins

Axin Signaling Complex has parent Multiprotein Complexes

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