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Enzyme or Coenzyme

Apoptosis Inducing Factor

AMW:CHEM:081046

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

Biochemistry biochemical
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Apoptosis Inducing Factor has parent Apoptosis Regulatory Proteins
Apoptosis Inducing Factor has parent Flavoproteins
Apoptosis Inducing Factor has parent NADH, NADPH Oxidoreductases
Apoptosis Inducing Factor has parent Poly-ADP-Ribose Binding Proteins

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