Carbohydrate

ATP Binding Cassette Transporter, Subfamily B

AMW:CHEM:090096

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Biochemistry biochemical

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ATP Binding Cassette Transporter, Subfamily B, Member 1 has parent ATP Binding Cassette Transporter, Subfamily B

ATP Binding Cassette Transporter, Subfamily B, Member 2 has parent ATP Binding Cassette Transporter, Subfamily B

ATP Binding Cassette Transporter, Subfamily B, Member 3 has parent ATP Binding Cassette Transporter, Subfamily B

ATP Binding Cassette Transporter, Subfamily B, Member 11 has parent ATP Binding Cassette Transporter, Subfamily B

ATP-Binding Cassette Sub-Family B Member 4 has parent ATP Binding Cassette Transporter, Subfamily B

ATP Binding Cassette Transporter, Subfamily B has parent ATP-Binding Cassette Transporters

ATP Binding Cassette Transporter, Subfamily B has parent Organic Anion Transporters, ATP-Dependent

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