Mechanism

Unfolded Protein Response

AMW:PHYS:020269

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

Physiology functional

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Unfolded Protein Response has parent Endoplasmic Reticulum Stress

Unfolded Protein Response has parent Protein Processing, Post-Translational

Endoplasmic Reticulum-Associated Degradation has parent Unfolded Protein Response

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