Physiological Process

Loss of Heterozygosity

AMW:PHYS:050331

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

Physiology functional

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Loss of Heterozygosity has parent Allelic Imbalance

Haploinsufficiency has parent Loss of Heterozygosity

Chromosome Deletion has parent Loss of Heterozygosity

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